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Dr. Elah Pick

Senior Lecturer

Phone: 972-4-9838988

Email: elahpic@research.haifa.ac.il

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Education

1999 - PhD (Biology), Technion - Israel Institute of Technology

1994 - M.Sc. (Biochemistry), Tel Aviv University

1993 - B.Sc. (Biology), University of Haifa at Oranim

 

Research Interests

Research in our laboratory includes evolutionary and mechanistic aspects of quality-control regulators, especially the multifunctional COP9 signalosome (CSN) complex, a key regulator of the ubiquitin-proteasome system. The CSN is composed of eight subunits, each of them exhibit an extraordinary homology to a parallel subunit within the 26S proteasome lid subcomplex (also known as paralogy). We are studying the composition and function of this complex across phyla, as well as the nature of its interactions with a large number of counterpart proteins, and the role of these interactions in mediating protein degradation. An additional interest of our lab is to decipher the cross talk between the proteasome lid and the CSN paralog complexes. We are using the budding yeast Saccharomyces cerevisiae as the main model system; however approaching also mammalian cell lines and in-vitro systems for our studies.

 

Selected Publications

The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN(-) Domain. Pick E, Golan A, Zimbler JZ, Guo L, Sharaby Y, Tsuge T, Hofmann K, Wei N. PLoS One. (2012) 7:e43980. Epub 2012

Dual function of Rpn5 in two PCI complexes, the 26S proteasome and the COP9 signalosome. Yu, Z., Klifeld, O., Lande-Atir A., Bsoul, M., kleiman, M., krutauz, D., Book, A., Vierstra, A.D., Hofmann, K., Glickman, M.H.+, Pick, E+. (2011) Molecular Biology of the Cell 22:911-20. FFA=6{Faculty of 1000: 2011. F1000.com/}

PCI Complexes: Beyond the proteasome, CSN, and eIF3 troika. Pick, E.+, Hofmann K. and Glickman M.H.+ (2009) Molecular Cell 35: 260-264

In the land of the rising sun with the COP9 signalosome and related Zomes. Symposium on the COP9 signalosome, proteasome and eIF3. Pick, E.+ and Pintard, L+ (2009) European Molecular Biology Organization (EMBO) Reports 10: 343-348

Pick, E., Lau, O., Tsuge, T., Tong, Y., Menon, S., Dohmae, N., Plafker, S., Deng, X.W. and Wei, N. (2007) Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin. Molecular and Cellular Biology 27: 4708-4719 FFA=6 {Faculty of 1000: 2009. F1000.com/}

Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain. Rinaldi, T. #, Pick, E. #, Gambadoro, A., Zilli, S., Maytal-Kivity, V., Frontali, L. and Glickman, M.H. (2004) Biochemical Journal 381: 275-285

The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity, V., Pick, E., Piran, R., Hofmann, K. and Glickman, M.H. (2003) The International Journal of Biochemistry & Cell Biology 35: 706-715

A COP9 signalosome-like complex (CSN) is a regulator of mating pheromone response in S. cerevisiae. Maytal-Kivity, V.#, Piran, R.#, Pick, E.#, Hofmann, K. and Glickman, M.H. (2002) European Molecular Biology Organization (EMBO) Reports 3: 1215-1221

 

 

 

Teaching

Molecular Biology, Cell Biology, Genetic Engineering Workshop, Environmental Effects on Genome Integrity

 

A COP9 signalosome-like complex (CSN) is a regulator of mating pheromone response in S. cerevisiae. Maytal-Kivity, V.#, Piran, R.#, Pick, E.#, Hofmann, K. and Glickman, M.H. (2002) European Molecular Biology Organization (EMBO) Reports 3: 1215-1221 Normal 0 false false false EN-US X-NONE HE