אודות
Our research aim is to understand how simple sensory information is encoded, consolidated and maintained in the cortex and elucidate the biological mechanisms underlying memory formation and consolidation in the mammalian brain. Since our research is inherently multi-disciplinary, we combine research approaches from the field of biology, as well as psychology, integrating data ranging from the molecular to whole animal level. In our laboratory we employ state of the art equipment (e.g., confocal microscope, real-time PCR, electrophysiology, biochemistry and molecular biology), as well as a broad spectrum of techniques both in vitro and in vivo for the study of normal and abnormal cognitive function in behaving animals. Following recent results regarding the role of translation regulation in normal learning processes, we test the hypothesis that mal-function of similar biochemical pathways underlies cognitive dysfunction and sporadic Alzheimer's disease.
פרסומים
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025, MCCS-NYUAD Panel, Dec 2026, In: Molecular Brain. 19, 1, 21.
- Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior, Jester, H. M., Nicol, N., Yang, Q., Zhang, Y., Suhocki, A., Zhou, X., Underwood, E., Pourhadi, H., Cheng, D., Lee, J., Sun, P., Furdui, C. M., Proud, C. G., Rosenblum, K. & Ma, T., May 2026, In: Molecular Psychiatry. 31, 5, p. 2454-2471 18 p.
- Linking sensory experience to bodily states in the insular cortex, Yiannakas, A., Kayyal, H., Kolatt Chandran, S. & Rosenblum, K., 2026, (Accepted/In press) In: Trends in Neurosciences.
- Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition, Izkovich, B., Yiannakas, A., Ne’eman, S., Chandran, S. K., Rosenblum, K. & Edry, E., Dec 2025, In: Molecular Brain. 18, 1, 19.
- Inhibiting 5-HT2C receptor in the hippocampus rescues EphB2-dependent memory impairment in mice, Jana, S., Chandran, S. K., Rosenblum, K. & Lamprecht, R., 5 Aug 2025, In: European Journal of Pharmacology. 1000, 177729.
- Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit, Kayyal, H., Cruciani, F., Chandran, S. K., Edry, E., Schif-Zuck, S., Koren, T., Yiannakas, A., Rolls, A., Ariel, A. & Rosenblum, K., Mar 2025, In: Nature Neuroscience. 28, 3, p. 589-601 13 p., 3983.
- NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics, Ruggiero, A., Heim, L. R., Susman, L., Hreaky, D., Shapira, I., Katsenelson, M., Rosenblum, K. & Slutsky, I., 22 Jan 2025, In: Neuron. 113, 2, p. 244-259.e7
- Licking microstructure behavior classifies a spectrum of emotional states in mice, Salalha, R., Holzman, M., Cruciani, F., David, G. B., Amir, Y., Mawase, F. & Rosenblum, K., 2025, In: Frontiers in Systems Neuroscience. 19, 1623084.
- Novel sulfonamide series of qr2 inhibitors to tackle oxidative stress and cognitive decline, Rosenblum, K. (Inventor) & Gould, N. (Inventor), 11 Jul 2024, IPC No. US18, Patent No. 284,840, 30 Mar 2026
- Compositions and methods for delivery and expression of small inhibitory peptides and use thereof, Rosenblum, K. (Inventor) & Edry, E. (Inventor), 2024, IPC No. US18, Patent No. 433,660, 20 Mar 2018
- Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice, Gould, N. L., Scherer, G. R., Carvalho, S., Shurrush, K., Kayyal, H., Edry, E., Elkobi, A., David, O., Foqara, M., Thakar, D., Pavesi, T., Sharma, V., Walker, M., Maitland, M., Dym, O., Albeck, S., Peleg, Y., Germain, N., Babaev, I. & Sharir, H. & 13 others, , 15 Aug 2023, In: Journal of Clinical Investigation. 133, 19, e162120.
- Messenger RNA Translation Defects in Neurodegenerative Diseases., Burwick, N., Aktas, B. H., Storkebaum, E., Rosenblum, K. & Sonenberg, N., 2023, In: New England Journal of Medicine. 388, 22, p. 2110-2111 2 p.
- Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence, Chandran, S. K., Yiannakas, A., Kayyal, H., Salalha, R., Cruciani, F., Mizrahi, L., Khamaisy, M., Stern, S. & Rosenblum, K., 23 May 2022, In: bioRxiv.
- Remembering immunity: Neuronal ensembles in the insular cortex encode and retrieve specific immune responses, Koren, T., Krot, M., Boshnak, N. T., Amer, M., Ben-Shaanan, T. L., Azulay-Debby, H., Hajjo, H., Avishai, E., Schiller, M., Haykin, H., Korin, B., Cohen-Farfara, D., Hakim, F., Rosenblum, K. & Rolls, A., 3 Dec 2020.
- Mnemonic-like representation of immune-related information in the insular cortex: PNIRS 2019, Koren, T., Krot, M., Boshnak, N. T., Ben-Shaanan, T. L., Schiller, M., Azulay-Debby, H., Korin, B., Hajjo, H., Avishai, E., Amer, M., Haykin, H., Rosenblum, K. & Rolls, A., 2019, In: Brain, Behavior, and Immunity. 81, Supplement, p. 8 1 p., 3237.
- Gustatory-immune integration in the insular cortex: PNIRS 2019, Krot, M., Koren, T., Avishai, E., Schiller, M., Boshnak, N. T., Hajjo, H., Amer, M., Haykin, H., Ben-Shaanan, T. L., Azulay-Debby, H., Hakim, F., Rosenblum, K. & Rolls, A., 2019, In: Brain, Behavior, and Immunity. 81, Supplement, p. 8-9 2 p., 3238.
- MEK/mTOR-dependent D1 dopamine receptor activation induces local protein synthesis via eEF2 dephosphorylation in neurons, David, O., Barrera, I., Koltun, B., Ironi, S., Gal-Ben Ari, S. & Rosenblum, K., 1 Jan 2018, 57 p.
- Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice, Sharma, V., Cohen, N., Sood, R., Ounallah-Saad, H., Gal Ben-Ari, S. & Rosenblum, K., 2018, In: Bio-protocol. 8, 16, p. e2475
- Genetic or pharmacological reduction of PERK enhances cortical- and hippocampus-dependent cognitive function, Rosenblum, K. (Inventor), Sharma, V. (Inventor) & Ounallah-Saad, H. (Inventor), 2016, IPC No. US15, Patent No. 335,466
- Methods for improving cognitive function via modulation of quinone reductase 2, Rosenblum, K. (Inventor) & Rappaport, A. (Inventor), 18 Mar 2015, IPC No. US15, Patent No. 126,291
- Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information, David, O., Barrera, I., Chinnakkaruppan, A., Kaphzan, H., Nakazawa, T., Yamamoto, T. & Rosenblum, K., 18 Jul 2014, In: Frontiers in Molecular Neuroscience. 7, JULY, 66.
- Enhancing memory via knockdown of eIF2 alpha kinase PERK: The 22nd Annual Meeting of the Israel Society for Neuroscience (ISFN) & The 2nd Bi national Italy-Israel Neuroscience Meeting, Sharma, V., Ounallah-Saad, H. & Rosenblum, K., 12 Mar 2014, In: Journal of Molecular Neuroscience. 53, S1, p. S114 1 p.
- How a taste memory is waiting hours for visceral information to form conditioned taste aversion? The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Chinnakkaruppan, A. & Rosenblum, K., Nov 2013, In: Journal of Molecular Neuroscience. 51, S1, p. S4 1 p.
- Novel and familiar taste learning elicit different network: The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Elkobi, A., Inberg, S. & Rosenblum, K., Nov 2013, In: Journal of Molecular Neuroscience. 51, S1, p. S35 1 p.
- Inhibition of the proteasome bi-directionally learning and memory processes in the GC: The Israel Society for Neuroscience 20th Annual Meeting Hilton Queen of Sheba Eilat, December 11–13, 2011, Rosenberg, T., Elkobi, A. & Rosenblum, K., Nov 2012, In: Journal of Molecular Neuroscience. 48, S1, p. S98 1 p.
- Novel and familiar taste learning elicit different network activity in thegustatory cortex: The Israel Society for Neuroscience 20th Annual Meeting Hilton Queen of Sheba Eilat, December 11–13, 2011, Inberg, S., Elkobi, A. & Rosenblum, K., Nov 2012, In: Journal of Molecular Neuroscience. 48, S1, p. S54-S55 2 p.
- The role of protein phosphorylation in the gustatory cortex and amygdala during taste learning, Adaikkan, C. & Rosenblum, K., Jun 2012, In: Experimental Neurobiology. 21, 2, p. 37-51 15 p.
- Inhibition of the Proteasome Affects Learning and Memory: 23rd Biennial Meeting of ISN/ESN, Athens, Greece, 28 August ‐ 1 September 2011, Rosenblum, K., Rosenberg, T., Elkobi, A. & Inberg, S., 31 Aug 2011, In: Journal of Neurochemistry. 118, S1, p. 176 1 p.
- Dopamine and tyrosine phosphorylation of NR2B (Y1472) in the hippocampus is fundamental for ERK2 activation and novel learning: 23rd Biennial Meeting of ISN/ESN, Athens, Greece, 28 August ‐ 1 September 2011, David, O., Nakazwa, T., Yamamoto, T. & Rosenblum, K., 30 Aug 2011, In: Journal of Neurochemistry. 118, S1, p. 160 1 p.
- The role of AKT phosphiorylation in acquisition and extinction of conditioned taste aversion: The Israel Society for Neuroscience 19th Annual Meeting Eilat, Dec. 12 - 14, 2010 www.isfn.org.il, Slouzkey, I., Rosenblum, K. & Maroun, M., 2011, In: Journal of Molecular Neuroscience. 45, S1, p. S115 1 p.
- Virally mediated gene manipulation in the adult CNS, Edry, E., Lamprecht, R., Wagner, S. & Rosenblum, K., 2011, In: Frontiers in Molecular Neuroscience. 4, p. 1-6 6 p.
- ERKII-Dependent PSD-95 Induction in the Gustatory Cortex is Necessary for Taste Learning but Not Retrieval, Rosenblum, K., 1 Mar 2009, In: Chemical Senses. 34, 3, p. E7 1 p.
- Molecular Mechanisms of Taste Learning in the Insular Cortex and Amygdala: Conditioned Taste Aversion Behavioral and Neural Processes, Barki-Harrington, L., Belelovsky, K., Doron, G. & Rosenblum, K., 2008, Conditioned Taste Aversion Behavioral and Neural Processes. Reilly, S. & Schachtman, T. R. (eds.). Oxford University Press, p. 341–363 23 p.
- Translation regulation underlying taste memory consolidation: 21st Biennial Meeting of the International Society for Neurochemistry and the 38th Annual Meeting of the American Society for Neurochemistry, Cancún, Mexico, 19–24 August 2007 (Monday Session), Rosenblum, K., 6 Aug 2007, In: Journal of Neurochemistry. 102, S1, p. 3 1 p.
- Initiation regulation of eIF2alpha during taste learning and consolidation: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Stern, E., Merhav, M., Costa-Mattioli, M., Sonenberg, N. & Rosenblum, K., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S62-S63 2 p.
- Translation regulation in the insular cortex during taste memory consolidation: Abstracts of the joint Germany - Israel Meeting on The Neural Basis of Behavior, Rosenblum, K., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S76 1 p.
- The medial prefrontal cortex is involved in extinction of conditioned taste aversion: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Khatsrinov, V., Akirav, I., Vouimba, R. M., Guillaume, F., Rosenblum, K. & Maroun, M., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S36 1 p.
- The role of tyrosine phosphorylation in novel taste learning: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Barki-Harrington, L., Elkobi, A. & Rosenblum, K., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S7 1 p.
- MAPK activation is highly dependent on experimental procedure in LTP studies in vivo: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Belelovsky, K., Maroun, M. & Rosenblum, K., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S8 1 p.
- Juvenile stress-induced alteration of GABAA Receptor alpha Subunit maturation in the rat: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Jacobson-Pick, S., Vender, S., Elkobi, A., Rosenblum, K. & Richter Levin, G., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S33 1 p.
- Exposure to behavioral stress impairs extinction of conditioned taste aversion: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Motanis, H. K., Akirav, I., Vouimba, R. M., Merhav, M., Rosenblum, K. & Maroun, M., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S48 1 p.
- Learning-induced modifications in small conductance (SK) potassium channels in cortical pyramidal neurons: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Brosh, I., Rosenblum, K. & Barkai, E., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S13 1 p.
- Simple and complex olfactory-discrimination learning tasks differ by their manifestation in excitability state of the pyramidal neurons: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Cohen-Matsliah, S. I., Rosenblum, K. & Barkai, E., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S15 1 p.
- 5''TOP and Cap dependent translation modulate taste learning and memory: Abstracts of the 14th Annual Meeting of the Israel Society for Neuroscience, Merhav, M., Belelovsky, K., Rosenblum, K., Klann, E. & Antion, M. D., Oct 2005, In: Reviews in the Neurosciences. 16, Supplement, p. S47 1 p.
- The role of ERKI/II in late phase LTP: 2001 International Society for Neurochemistry, Rosenblum, K., 2001, In: Journal of Neurochemistry. 78, S1, p. 117 1 p.
- The role of MAP kinase in late phase LTP, Rosenblum, K., Futter, M., Voss, K. L., Skehel, P. A. & Bliss, T. V. P., 2000, In: European Journal of Neuroscience. 12, p. 250 1 p.
- ERKII-GFP translocation to the nucleus, a possible indicator of long-term synaptic plasticity in-vivo, Rosenblum, K., Futter, M., Hulme, E. C., Skehel, P. A. & Bliss, T. V. P., Nov 1999, In: Neuroscience Letters. p. S34 1 p.
- The NMDA receptor subunit 2B: A molecular saliency switch in the mammalian brain, Dudai, Y., Rosenblum, K., Berman, D., Lamprecht, R., Richter Levin, G., Maroun, M. & Hazvi, S., 1997, In: Journal of Neurochemistry. 69, p. S96 1 p.
- Mechanisms of taste and odor learning in rodents: the role of protein tyrosine phosphorylation, protein synthesis and degradation, and gene expression: Eleventh Congress of European Chemoreception Research Organisation (ECRO XI), Dudai, Y., Hazvi, S., Lamprecht, R., Meiri, N., Miskin, R., Naor, C., Rosenblum, K. & Schul, R., 1995, In: Chemical Senses. 20, 1, p. 107 1 p.
- The Tyrosine Phosphorylation of a 180kD Synaptosomal Protein in the Insular Cortex of the Rat Is Modulated by Taste Learning, Rosenblum, K., Dorais, A., Schul, R., Meiri, N., Hazvi, S. & Dudai, Y., Dec 1994, In: Journal of Neurochemistry. 63, S1, p. S60 1 p.