אודות
We study the local circuit mechanisms underlying cognition
Our unique approach enables us to bi-directionally interface with the intact brain at the spatiotemporal resolution of small groups of neurons or even individual neurons in freely-moving rodents. This allows us to "erase" and "write" individual spikes during specific times while observing the effects of these manipulations on network activity and cognitive behavior.
פרסומים
- Converging assemblies: A putative building block for brain function and for interfacing with the brain, Stark, E. & Spivak, L., 1 Mar 2026, In: Neural Regeneration Research. 21, 3, p. 1124-1125 2 p.
- Social remapping of spatial coding along the dorsoventral axis of the mouse prefrontal cortex, Cohen, L., Mohapatra, A. N., Netser, S., Wagner, S. & Stark, E., 28 Oct 2025, In: Cell Reports. 44, 10, 116319.
- The generation of a neuronal phase code for space, Stark, E. & Sloin, H. E., Nov 2024, In: Clinical and Translational Medicine. 14, 11
- Learning to learn: Single session acquisition of new rules by freely moving mice, Levi, A., Aviv, N. & Stark, E., 1 May 2024, In: PNAS Nexus. 3, 5, pgae203.
- Local activation of CA1 pyramidal cells induces theta-phase precession, Sloin, H. E., Spivak, L., Levi, A., Gattegno, R., Someck, S. & Stark, E., 20 Feb 2024, In: Science. 383, 6682, p. 551-558 8 p.
- Wired together, change together: Spike timing modifies transmission in converging assemblies, Spivak, L., Someck, S., Levi, A., Sivroni, S. & Stark, E., 2024, In: Science Advances. 10, 3
- Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes, Someck, S., Levi, A., Sloin, H. E., Spivak, L., Gattegno, R. & Stark, E., Dec 2023, In: Communications Biology. 6, 1, 950.
- Short-term auditory priming in freely-moving mice, Sivroni, S., Sloin, H. E. & Stark, E., 20 Oct 2023, In: iScience. 26, 10, 107847.
- Deconvolution improves the detection and quantification of spike transmission gain from spike trains, Spivak, L., Levi, A., Sloin, H. E., Someck, S. & Stark, E., Dec 2022, In: Communications Biology. 5, 1, 520.
- Cortical Pyramidal and Parvalbumin Cells Exhibit Distinct Spatiotemporal Extracellular Electric Potentials, Sukman, L. J. & Stark, E., 1 Nov 2022, In: eNeuro. 9, 6, ENEURO.0265-22.2022.
- Network resonance can be generated independently at distinct levels of neuronal organization, Stark, E., Levi, A. & Rotstein, H. G., Jul 2022, In: PLOS Computational Biology. 18, 7, e1010364.
- Hybrid Offspring of C57BL/6J Mice Exhibit Improved Properties for Neurobehavioral Research, Sloin, H. E., Bikovski, L., Levi, A., Amber-Vitos, O., Katz, T., Spivak, L., Someck, S., Gattegno, R., Sivroni, S., Sjulson, L. & Stark, E., 1 Jul 2022, In: eNeuro. 9, 4, p. 1-16 16 p., ENEURO.0221-22.2022.
- High Fidelity Theta Phase Rolling of CA1 Neurons, Sloin, H. E., Levi, A., Someck, S., Spivak, L. & Stark, E., 13 Apr 2022, In: Journal of Neuroscience. 42, 15, p. 3184-3196 13 p.
- Outan: An On-Head System for Driving μlED Arrays Implanted in Freely Moving Mice, Tarnavsky Eitan, A., Someck, S., Zajac, M., Socher, E. & Stark, E., Apr 2021, In: IEEE Transactions on Biomedical Circuits and Systems. 15, 2, p. 303-313 11 p., 9385944.
- Response and sample bridging in a primate short-term memory task, Sloin, H. & Stark, E., Dec 2019, In: Neurobiology of Learning and Memory. 166, 107106.
- A novel low-noise movement tracking system with real-time analog output for closed-loop experiments, Gaspar, N., Eichler, R. & Stark, E., 15 Apr 2019, In: Journal of Neuroscience Methods. 318, p. 69-77 9 p.
- Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes, Kampasi, K., English, D. F., Seymour, J., Stark, E., McKenzie, S., Vöröslakos, M., Buzsáki, G., Wise, K. D. & Yoon, E., 1 Dec 2018, In: Microsystems and Nanoengineering. 4, 1, 10.
- Sharp wave ripples during learning stabilize the hippocampal spatial map, Roux, L., Hu, B., Eichler, R., Stark, E. & Buzsáki, G., 1 Jun 2017, In: Nature Neuroscience. 20, 6, p. 845-853 9 p.
- Spike-centered jitter can mistake temporal structure, Platkiewicz, J., Stark, E. & Amarasingham, A., 1 Mar 2017, In: Neural Computation. 29, 3, p. 783-803 21 p.
- GaN-on-Si μlED optoelectrodes for high-spatiotemporal-accuracy optogenetics in freely behaving animals, Kim, K., English, D., McKenzie, S., Wu, F., Stark, E., Seymour, J., Ku, P. C., Wise, K., Buzsaki, G. & Yoon, E., Dec 2016, 2016 IEEE International Electron Devices Meeting, IEDM 2016. Institute of Electrical and Electronics Engineers Inc., p. 26.5.1-26.5.4 7838486. (Technical Digest - International Electron Devices Meeting, IEDM; vol. 0).
- Fiberless multicolor neural optoelectrode for in vivo circuit analysis, Kampasi, K., Stark, E., Seymour, J., Na, K., Winful, H. G., Buzsáki, G., Wise, K. D. & Yoon, E., 3 Aug 2016, In: Scientific Reports. 6, 30961.
- Local generation of multineuronal spike sequences in the hippocampal CA1 region, Stark, E., Roux, L., Eichler, R. & Buzsáki, G., 18 Aug 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. 10521-10526 6 p.
- Tools for probing local circuits: High-density silicon probes combined with optogenetics, Buzsáki, G., Stark, E., Berényi, A., Khodagholy, D., Kipke, D. R., Yoon, E. & Wise, K. D., 8 Apr 2015, In: Neuron. 86, 1, p. 92-105 14 p.
- Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals, Wu, F., Stark, E., Ku, P. C., Wise, K. D., Buzsáki, G. & Yoon, E., 2015, In: Neuron. 88, 6, p. 1136-1148 13 p.
- Excitation and inhibition compete to control spiking during hippocampal ripples: Intracellular study in behaving mice, English, D. F., Peyrache, A., Stark, E., Roux, L., Vallentin, D., Long, M. A. & Buzsáki, G., 3 Dec 2014, In: Journal of Neuroscience. 34, 49, p. 16509-16517 9 p.
- Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations, Stark, E., Roux, L., Eichler, R., Senzai, Y., Royer, S. & Buzsáki, G., 16 Jul 2014, In: Neuron. 83, 2, p. 467-480 14 p.
- In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes, Roux, L., Stark, E., Sjulson, L. & Buzsáki, G., Jun 2014, In: Current Opinion in Neurobiology. 26, p. 88-95 8 p.
- Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals, Berényi, A., Somogyvári, Z., Nagy, A. J., Roux, L., Long, J. D., Fujisawa, S., Stark, E., Leonardo, A., Harris, T. D. & Buzsáki, G., 1 Mar 2014, In: Journal of Neurophysiology. 111, 5, p. 1132-1149 18 p.
- Inhibition-Induced theta resonance in cortical circuits, Stark, E., Eichler, R., Roux, L., Fujisawa, S., Rotstein, H. G. & Buzsáki, G., 4 Dec 2013, In: Neuron. 80, 5, p. 1263-1276 14 p.
- An implantable neural probe with monolithically integrated dielectric waveguide and recording electrodes for optogenetics applications, Wu, F., Stark, E., Im, M., Cho, I. J., Yoon, E. S., Buzsáki, G., Wise, K. D. & Yoon, E., Oct 2013, In: Journal of Neural Engineering. 10, 5, 056012.
- Implantable neural probes for chronic electrical recording and optical stimulation, Wu, F., Stark, E., Im, M., Cho, I. J., Tien, L., Chen, F., Yoon, E. S., Buzsaki, G., Kaplan, D., Berke, J., Wise, K. D. & Yoon, E., 2013, 2013 IEEE International Electron Devices Meeting, IEDM 2013. p. 8.6.1-8.6.4 6724589. (Technical Digest - International Electron Devices Meeting, IEDM).
- Diode probes for spatiotemporal optical control of multiple neurons in freely moving animals, Stark, E., Koos, T. & Buzsáki, G., 1 Jul 2012, In: Journal of Neurophysiology. 108, 1, p. 349-363 15 p.
- Large-scale recording of neurons by movable silicon probes in behaving rodents, Vandecasteele, M., Royer, S., Belluscio, M., Berényi, A., Diba, K., Fujisawa, S., Grosmark, A., Mao, D., Mizuseki, K., Patel, J., Stark, E., Sullivan, D., Watson, B. & Buzsáki, G., 4 Mar 2012, In: Journal of Visualized Experiments. 61, e3568.
- GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons, English, D. F., Ibanez-Sandoval, O., Stark, E., Tecuapetla, F., Buzsáki, G., Deisseroth, K., Tepper, J. M. & Koos, T., Jan 2012, In: Nature Neuroscience. 15, 1, p. 123-130 8 p.
- Transcranial electric stimulation entrains cortical neuronal populations in rats, Ozen, S., Sirota, A., Belluscio, M. A., Anastassiou, C. A., Stark, E., Koch, C. & Buzsáki, G., 25 Aug 2010, In: Journal of Neuroscience. 30, 34, p. 11476-11485 10 p.
- Unbiased estimation of precise temporal correlations between spike trains, Stark, E. & Abeles, M., 30 Apr 2009, In: Journal of Neuroscience Methods. 179, 1, p. 90-100 11 p.
- The minimum information principle and its application to neural code analysis (Proceeding of the National Academy of Sciences of the United States of America (2009) 106, 9, (3490-3495) doi: 10.1073/pnas.0806782106), Globerson, A., Stark, E., Vaadia, E. & Tishby, N., 10 Mar 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 4061 1 p.
- The minimum information principle and its application to neural code analysis, Globerson, A., Stark, E., Vaadia, E. & Tishby, N., 3 Mar 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3490-3495 6 p.
- Motor cortical activity related to movement kinematics exhibits local spatial organization, Stark, E., Drori, R. & Abeles, M., Mar 2009, In: Cortex. 45, 3, p. 418-431 14 p.
- Parabolic movement primitives and cortical states: Merging optimality with geometric invariance, Polyakov, F., Stark, E., Drori, R., Abeles, M. & Flash, T., Feb 2009, In: Biological Cybernetics. 100, 2, p. 159-184 26 p.
- Correlations between groups of premotor neurons carry information about prehension, Stark, E., Globerson, A., Asher, I. & Abeles, M., 15 Oct 2008, In: Journal of Neuroscience. 28, 42, p. 10618-10630 13 p.
- Dependence of neuronal correlations on filter characteristics and marginal spike train statistics, Tetzlaff, T., Rotter, S., Stark, E., Abeles, M., Aertsen, A. & Diesmann, M., Sep 2008, In: Neural Computation. 20, 9, p. 2133-2184 52 p.
- Predicting movement from multiunit activity, Stark, E. & Abeles, M., 1 Aug 2007, In: Journal of Neuroscience. 27, 31, p. 8387-8394 8 p.
- Encoding of reach and grasp by single neurons in premotor cortex is independent of recording site, Stark, E., Asher, I. & Abeles, M., May 2007, In: Journal of Neurophysiology. 97, 5, p. 3351-3364 14 p.
- Comparison of direction and object selectivity of local field potentials and single units in macaque posterior parietal cortex during prehension, Asher, I., Stark, E., Abeles, M. & Prut, Y., May 2007, In: Journal of Neurophysiology. 97, 5, p. 3684-3695 12 p.
- Spike sorting: Bayesian clustering of non-stationary data, Bar-Hillel, A., Spiro, A. & Stark, E., 30 Oct 2006, In: Journal of Neuroscience Methods. 157, 2, p. 303-316 14 p.
- Erratum: Partial cross-correlation analysis resolves ambiguity in the encoding of multiple movement features (Journal of Neurophysiology (March 2006) 95, (1966-1975) DOI: 10.1152/jn.00981.2005), Stark, E., Drori, R. & Abeles, M., 2006, In: Journal of Neurophysiology. 96, 2, p. 965 1 p.
- Applying resampling methods to neurophysiological data, Stark, E. & Abeles, M., 30 Jun 2005, In: Journal of Neuroscience Methods. 145, 1-2, p. 133-144 12 p.
- Spike sorting: Bayesian clustering of non-stationary data, Bar-Hillel, A., Spiro, A. & Stark, E., 2005, Advances in Neural Information Processing Systems 17 - Proceedings of the 2004 Conference, NIPS 2004. Neural information processing systems foundation, (Advances in Neural Information Processing Systems).
- Neuronal Activity in Motor Cortical Areas Reflects the Sequential Context of Movement, Ben-Shaul, Y., Drori, R., Asher, I., Stark, E., Nadasdy, Z. & Abeles, M., Apr 2004, In: Journal of Neurophysiology. 91, 4, p. 1748-1762 15 p.