אודות
Head, The Laboratory for Molecular Pathways in the Resolution of Inflammation
פרסומים
- IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving inflammation in male mice, Zeituni-Timor, O., Soboh, S., Zaid, A., Yaseen, H., Kumaran Satyanarayanan, S., Abu Zeid, M., Silberberg, E., Goswami, P., Schif-Zuck, S., Larisch, S. & Ariel, A., Dec 2025, In: Communications Biology. 8, 1, 1269.
- Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway, Amer, J., Salhab, A., Ariel, A. & Safadi, R., Jul 2025, In: Cells. 14, 13, 941.
- Targeting dormant disseminated tumor cells and their permissive niche by pro-resolving mediators derived from resolution-phase macrophages, Gilon-Zaltsman, O., Weidenfeld-Barenboim, K., Samara, H., Feuermann, Y., Michaeli-Ashkenasi, S., Schif-Zuck, S., Von Huth, P., Butenko, S., Assi, S., Sabo, E., Ariel, A. & Barkan, D., 1 Mar 2025, In: Cancer Letters. 612, 217468.
- Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit, Kayyal, H., Cruciani, F., Chandran, S. K., Edry, E., Schif-Zuck, S., Koren, T., Yiannakas, A., Rolls, A., Ariel, A. & Rosenblum, K., Mar 2025, In: Nature Neuroscience. 28, 3, p. 589-601 13 p., 3983.
- Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders, Zaid, A. & Ariel, A., Apr 2024, In: Advanced Drug Delivery Reviews. 207, 115204.
- Interferon-stimulated neutrophils as a predictor of immunotherapy response, Benguigui, M., Cooper, T. J., Kalkar, P., Schif-Zuck, S., Halaban, R., Bacchiocchi, A., Kamer, I., Deo, A., Manobla, B., Menachem, R., Haj-Shomaly, J., Vorontsova, A., Raviv, Z., Buxbaum, C., Christopoulos, P., Bar, J., Lotem, M., Sznol, M., Ariel, A. & Shen-Orr, S. S. & 1 others, , 12 Feb 2024, In: Cancer Cell. 42, 2, p. 253-265.e12
- JMJD3 regulates diabetic wound repair in a STINGy fashion, Ariel, A., Jan 2023, In: Cellular and Molecular Immunology. 20, 1, p. 110-111 2 p.
- IFN-β mediates the anti-osteoclastic effect of bisphosphonates and dexamethasone, Kalkar, P., Cohen, G., Tamari, T., Schif-Zuck, S., Zigdon-Giladi, H. & Ariel, A., 14 Oct 2022, In: Frontiers in Pharmacology. 13, p. 1002550 1002550.
- Editorial: Molecular and Cellular Effectors in the Resolution of Inflammation, Ariel, A., Perruche, S., You, S. & Filep, J. G., 26 May 2022, In: Frontiers in Immunology. 13, 938819.
- Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis, Silberberg, E., Filep, J. G. & Ariel, A., 9 May 2022, In: Frontiers in Immunology. 13, p. 863449 863449.
- ACKR2 limits skin fibrosis and hair loss through IFN-β, Butenko, S., Ben Jashar, N., Sheffer, T., Sabo, E., Schif-Zuck, S. & Ariel, A., Oct 2021, In: FASEB Journal. 35, 10, e21917.
- Enteral and supplemental parenteral nutrition enriched with omega-3 polyunsaturated fatty acids in intensive care patients – A randomized, controlled, double-blind clinical trial, Singer, P., Bendavid, I., Mesilati-Stahy, R., Green, P., Rigler, M., Lev, S., Schif-Zuck, S., Amiram, A., Theilla, M. & Kagan, I., May 2021, In: Clinical Nutrition. 40, 5, p. 2544-2554 11 p.
- Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling, Khatib-Massalha, E., Bhattacharya, S., Massalha, H., Biram, A., Golan, K., Kollet, O., Kumari, A., Avemaria, F., Petrovich-Kopitman, E., Gur-Cohen, S., Itkin, T., Brandenburger, I., Spiegel, A., Shulman, Z., Gerhart-Hines, Z., Itzkovitz, S., Gunzer, M., Offermanns, S., Alon, R. & Ariel, A. & 1 others, , 1 Dec 2020, In: Nature Communications. 11, 1, 3547.
- Corrigendum: Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming, Lumbroso, D., Soboh, S., Maimon, A., Schif-Zuck, S., Ariel, A. & Burstyn-Cohen, T., 30 Nov 2020, In: Frontiers in Immunology. 11, 412281.
- The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation, Maimon, N., Zamir, Z. Z., Kalkar, P., Zeytuni-Timor, O., Schif-Zuck, S., Larisch, S. & Ariel, A., 1 Aug 2020, In: Apoptosis. 25, 7-8, p. 558-573 16 p.
- Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-β, Yaseen, H., Butenko, S., Polishuk-Zotkin, I., Schif-Zuck, S., Pérez-Sáez, J. M., Rabinovich, G. A. & Ariel, A., 17 Jun 2020, In: Frontiers in Pharmacology. 11, 901.
- Corrigendum: Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis: Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis, Butenko, S., Satyanarayanan, S. K., Assi, S., Schif-Zuck, S., Barkan, D., Sher, N. & Ariel, A., 20 May 2020, In: Frontiers in Immunology. 11, 1003.
- Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis, Butenko, S., Satyanarayanan, S. K., Assi, S., Schif-Zuck, S., Sher, N. & Ariel, A., 31 Mar 2020, In: Frontiers in Immunology. 11, 405.
- Resolution-associated lactoferrin peptides limit lps signaling and cytokine secretion from human macrophages, Lutaty, A., Soboh, S., Schif-Zuck, S. & Ariel, A., 2020, In: International Journal of Molecular Sciences. 21, 14, p. 1-14 14 p., 5166.
- Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: Subversion towards autoimmunity by proteinase 3, Thieblemont, N., Witko-Sarsat, V. & Ariel, A., Nov 2018, In: European Journal of Clinical Investigation. 48, e12990.
- A 17-kDa fragment of lactoferrin associates with the termination of inflammation and peptides within promote resolution, Lutaty, A., Soboh, S., Schif-Zuck, S., Zeituni-Timor, O., Rostoker, R., Podolska, M. J., Schauer, C., Herrmann, M., Muñoz, L. E. & Ariel, A., 28 Mar 2018, In: Frontiers in Immunology. 9, MAR, 644.
- Free circulating active elastase contributes to chronic inflammation in patients on hemodialysis, Khatib-Massalha, E., Michelis, R., Trabelcy, B., Gerchman, Y., Kristal, B., Ariel, A. & Sela, S., Feb 2018, In: American Journal of Physiology - Renal Physiology. 314, 2, p. F203-F209
- CCL5 promotes resolution-phase macrophage reprogramming in concert with the atypical chemokine receptor d6 and apoptotic polymorphonuclear cells, Aswad, M., Assi, S., Schif-Zuck, S. & Ariel, A., 15 Aug 2017, In: Journal of Immunology. 199, 4, p. 1393-1404 12 p.
- ‘This way please’: Apoptotic cells regulate phagocyte migration before and after engulfment, Ariel, A. & Ravichandran, K. S., 1 Jul 2016, In: European Journal of Immunology. 46, 7, p. 1583-1586 4 p.
- Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer, Sagiv, J. Y., Michaeli, J., Assi, S., Mishalian, I., Kisos, H., Levy, L., Damti, P., Lumbroso, D., Polyansky, L., Sionov, R. V., Ariel, A., Hovav, A. H., Henke, E., Fridlender, Z. G. & Granot, Z., 3 Feb 2015, In: Cell Reports. 10, 4, p. 562-573 12 p.
- Phospholipase A2 in experimental allergic bronchitis: A lesson from mouse and rat models, Mruwat, R., Yedgar, S., Lavon, I., Ariel, A., Krimsky, M. & Shoseyov, D., 29 Oct 2013, In: PLOS ONE. 8, 10, e76641.
- 15-Lipoxygenases in cancer: A double-edged sword?, Klil-Drori, A. J. & Ariel, A., Oct 2013, In: Prostaglandins and Other Lipid Mediators. 106, p. 16-22 7 p.
- Hanging in the balance: Endogenous anti-inflammatory mechanisms in tissue repair and fibrosis, Ariel, A. & Timor, O., Jan 2013, In: Journal of Pathology. 229, 2, p. 250-263 14 p.
- Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype, Rostoker, R., Yaseen, H., Schif-Zuck, S., Lichtenstein, R. G., Rabinovich, G. A. & Ariel, A., 2013, In: Prostaglandins and Other Lipid Mediators. 107, p. 85-94 10 p.
- The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation, Pashover-Schallinger, E., Aswad, M., Schif-Zuck, S., Shapiro, H., Singer, P. & Ariel, A., Sep 2012, In: FASEB Journal. 26, 9, p. 3891-3900 10 p.
- New lives given by cell death: Macrophage differentiation following their encounter with apoptotic leukocytes during the resolution of inflammation, Ariel, A. & Serhan, C. N., 2012, In: Frontiers in Immunology. 3, JAN, Article 4.
- Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids, Schif-Zuck, S., Gross, N., Assi, S., Rostoker, R., Serhan, C. N. & Ariel, A., Feb 2011, In: European Journal of Immunology. 41, 2, p. 366-379 14 p.
- Macrophages, meta-inflammation, and immuno-metabolism, Shapiro, H., Lutaty, A. & Ariel, A., 2011, In: Scientific World Journal. 11, p. 2509-2529 21 p.
- Resolvins and protectins in the termination program of acute inflammation, Ariel, A. & Serhan, C. N., Apr 2007, In: Trends in Immunology. 28, 4, p. 176-183 8 p.
- Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression, Ariel, A., Fredman, G., Sun, Y. P., Kantarci, A., Van Dyke, T. E., Luster, A. D. & Serhan, C. N., Nov 2006, In: Nature Immunology. 7, 11, p. 1209-1216 8 p.
- Removal of CCR5 ligands and induction of pro-resolving lipid mediators by apoptotic neutrophils during resolution, Serhan, C. N., Ariel, A., Fredman, G., Sun, Y. P., Kantarci, A., Van Dyke, T. E. & Luster, A. D., 2006, In: Protocol Exchange. 10 p.
- The docosatriene protectin D1 is produced by TH2 skewing promotes human T cell via lipid raft clustering, Ariel, A., Li, P. L., Wang, W., Tang, W. X., Fredman, G., Hong, S., Gotlinger, K. H. & Serhan, C. N., 30 Dec 2005, In: Journal of Biological Chemistry. 280, 52, p. 43079-43086 8 p.
- Erratum: Molecular circuits of resolution: Formation and actions of resolvins and protectins (Journal of Immunology (2005) 174 (4345-4355)), Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S. & Serhan, C. N., 1 May 2005, In: Journal of Immunology. 174, 9, p. 5884 1 p.
- Molecular circuits of resolution: Formation and actions of resolvins and protectins, Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S. & Serhan, C. N., 1 Apr 2005, In: Journal of Immunology. 174, 7, p. 4345-4355 11 p.
- Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-α secretion from human T cells, Ariel, A., Chiang, N., Arita, M., Petasis, N. A. & Serhan, C. N., 15 Jun 2003, In: Journal of Immunology. 170, 12, p. 6266-6272 7 p.
- IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components, Ariel, A., Novick, D., Rubinstein, M., Dinarello, C. A., Lider, O. & Hershkoviz, R., 1 Jul 2002, In: Journal of Leukocyte Biology. 72, 1, p. 192-198 7 p.
- Regulation of T cell- extracellular matrix (EMC) interactions by cytokines, chemokins and EMC-degrading enzymes, Ariel, A., Lider, O. & Cohen, I. R., 2002, Rehovot : The Weizmann Institute of Science.
- Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by elastase, Ariel, A., Hershkoviz, R., Altbaum-Weiss, I., Ganor, S. & Lider, O., 1 Mar 2001, In: Journal of Immunology. 166, 5, p. 3052-3060 9 p.
- Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1β secretion by intestinal epithelial cells, Chowers, Y., Lider, O., Schor, H., Barshack, I., Tal, R., Ariel, A., Bar-Meir, S., Cohen, I. R. & Cahalon, L., 2001, In: Gastroenterology. 120, 2, p. 449-459 11 p.
- Extracellular K+ and opening of voltage-gated potassium channels activate T cell integrin function: Physical and functional association between Kv1.3 channels and β1 integrins, Levite, M., Cahalon, L., Peretz, A., Hershkoviz, R., Sobko, A., Ariel, A., Desai, R., Attali, B. & Lider, O., 3 Apr 2000, In: Journal of Experimental Medicine. 191, 7, p. 1167-1176 10 p.
- Disaccharides generated from heparan sulphate or heparin modulate chemokine-induced T-cell adhesion to extracellular matrix, Hershkoviz, R., Schor, H., Ariel, A., Hecht, I., Cohen, I. R., Lider, O. & Cahalon, L., 2000, In: Immunology. 99, 1, p. 87-93 7 p.
- Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators, Ariel, A., Lider, O., Brill, A., Cahalon, L., Savion, N., Varon, D. & Hershkoviz, R., 2000, In: Immunology. 100, 3, p. 345-351 7 p.
- Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1, Rabinovich, G. A., Ariel, A., Hershkoviz, R., Hirabayashi, J., Kasai, K. I. & Lider, O., 1999, In: Immunology. 97, 1, p. 100-106 7 p.
- IL-2 induces T cell adherence to extracellular matrix: Inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase, Ariel, A., Yavin, E. J., Hershkoviz, R., Avron, A., Franitza, S., Hardan, I., Cahalon, L., Fridkin, M. & Lider, O., 1 Sep 1998, In: Journal of Immunology. 161, 5, p. 2465-2472 8 p.
- Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7, Ariel, A., Hershkoviz, R., Cahalon, L., Williams, D. E., Akiyama, S. K., Yamada, K. M., Chen, C., Alon, R., Lapidot, T. & Lider, O., Oct 1997, In: European Journal of Immunology. 27, 10, p. 2562-2570 9 p.